Article
The prevalence of the c-kit exon 10 variant, M541L, in aggressive fibromatosis does not differ from the general population.
Journal of clinical pathology - 1 Nov 2011
Grabellus Florian, Worm Karl, Sheu Sien-Yi, Siffert Winfried, Schmid Kurt W, Bachmann Hagen S
Abstract excerpt
BACKGROUND: The frequency of the c-kit exon 10 variant, M541L, (c.1621 A>C) in aggressive fibromatosis (AF) was recently determined to be 2.5-fold higher than in healthy controls. It was thus hypothesised that M541L could be associated with the development of AF. METHODS: 42 cases of sporadic AF were investigated for c-kit exon 10 alterations, by traditional sequencing. Subsequently, the AF cases and 126 healthy...
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