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[Relationship between the methylation and mutation of p53 gene and endemic arsenism caused by coal-burning].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] - 1 May 2011

Zhang Ai-hua, Pan Xue-li, Xia Yu-jie, Xiao Qian, Huang Xiao-xin

Abstract excerpt

OBJECTIVE: To explore the influence of arsenic pollution caused by coal-burning on methylation (promoter and exon 5) and mutation (exon 5) of human p53 gene, and to analyze the relationship between methylation, mutation and arsenism. METHODS: According to the diagnostic criteria of endemic arsenism, 112 patients with arsenism (including 38 mild cases, 43 moderate cases and 31 severe cases) were selected in the...

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PMID: 21756780

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