Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Yeast SCO1 protein is required for a post-translational step in the accumulation of mitochondrial cytochrome c oxidase subunits I and II.

Current genetics - 1 Jul 1990

Krummeck G, Rödel G

Abstract excerpt

Biogenesis of functional cytochrome c oxidase in yeast requires the product of the nuclear gene SCO1. Strains deleted for this gene fail to accumulate the mitochondrially-synthesized cytochrome c oxidase subunits I and II, despite the presence of the respective mRNAs. Here we present data which demonstrate that the observed phenotype does not result from a failure to translate the mRNAs, but from a preferential...

Topics

Electron Transport Complex IV
Electrophoresis
Fungal Proteins
Genes, Fungal
Membrane Proteins
Mitochondria
Mutation
Phenotype
Protein Processing, Post-Translational
Transformation, Genetic
Yeasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 2173976
DOI: 10.1007/BF00321109

Genes

SCO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2173976-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Yeast SCO1 protein is required for a post-translational step in the accumulation of mitochondrial cytochrome c oxidase subunits I and II.PMID 2173976Read ↗

Purification and characterization of yeast Sco1p, a mitochondrial copper protein.Semantic proximity Read ↗

A human SCO2 mutation helps define the role of Sco1p in the cytochrome oxidase assembly pathway.Semantic proximity Read ↗

The P174L mutation in human Sco1 severely compromises Cox17-dependent metallation but does not impair copper binding.Semantic proximity Read ↗

Human SCO2 is required for the synthesis of CO II and as a thiol-disulphide oxidoreductase for SCO1.Semantic proximity Read ↗

Mitochondrial copper metabolism in yeast: mutational analysis of Sco1p involved in the biogenesis of cytochrome c oxidase.Semantic proximity Read ↗

The human cytochrome c oxidase assembly factors SCO1 and SCO2 have regulatory roles in the maintenance of cellular copper homeostasis.Semantic proximity Read ↗

Mutation in sco affects cytochrome c assembly and alters oxidative stress resistance in Agrobacterium tumefaciens.Semantic proximity Read ↗

OXA1, a Saccharomyces cerevisiae nuclear gene whose sequence is conserved from prokaryotes to eukaryotes controls cytochrome oxidase biogenesis.Semantic proximity Read ↗

Suppressor mutations define two regions in the Cbp1 protein important for mitochondrial cytochrome b mRNA stability in Saccharomyces cerevisiae.Semantic proximity Read ↗

The importance of mutation, then and now: studies with yeast cytochrome c.Semantic proximity Read ↗

Mss51p, a putative translational activator of cytochrome c oxidase subunit-1 (COX1) mRNA, is required for synthesis of Cox1p in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mss51 and Ssc1 facilitate translational regulation of cytochrome c oxidase biogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.