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Article

Adenosine deaminase polymorphism affects sleep EEG spectral power in a large epidemiological sample.

PloS one - 1 Jan 2012

Mazzotti Diego Robles, Guindalini Camila, de Souza Altay Alves Lino, Sato João Ricardo, Santos-Silva Rogério, Bittencourt Lia Rita Azeredo, Tufik Sergio

Abstract excerpt

Slow wave oscillations in the electroencephalogram (EEG) during sleep may reflect both sleep need and intensity, which are implied in homeostatic regulation. Adenosine is strongly implicated in sleep homeostasis, and a single nucleotide polymorphism in the adenosine deaminase gene (ADA G22A) has been associated with deeper and more efficient sleep. The present study verified the association between the ADA G22A...

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Identifiers

PMID: 22952909
DOI: 10.1371/journal.pone.0044154
PMCID: PMC3430663

Genes

ADA

Variants

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