Article
GBA-associated PD presents with nonmotor characteristics.
Neurology - 19 Jul 2011
Brockmann K, Srulijes K, Hauser A K, Schulte C, Csoti I, Gasser T, Berg D
Abstract excerpt
OBJECTIVE: To evaluate whether there exists distinct characteristics in glucocerebrosidase (GBA)-associated Parkinson disease (PD) with regard to motor and nonmotor symptoms as well as imaging characteristics assessed by transcranial sonography (TCS). METHODS: Twenty patients with PD with heterozygous GBA mutations (N370S, L444P) (GBA-PD) in comparison to 20 patients with sporadic PD negative for GBA mutations...
Topics
- Age of Onset
- Aged
- Autonomic Nervous System Diseases
- Cognition Disorders
- Female
- Glucosylceramidase
- Humans
- Male
- Middle Aged
- Mutation
- Neuropsychological Tests
- Parkinson Disease
- Psychiatric Status Rating Scales
- Severity of Illness Index
- Statistics, Nonparametric
- Ultrasonography, Doppler, Transcranial