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Article

The diversities of PrP(Sc) distributions and pathologic changes in various brain regions from a Chinese patient with G114V genetic CJD.

Neuropathology : official journal of the Japanese Society of Neuropathology - 1 Feb 2012

Shi Qi, Zhang Bao-Yun, Gao Chen, Han Jun, Wang Gui-Rong, Chen Cao, Tian Chan, Dong Xiao-Ping

Abstract excerpt

Human genetic Creutzfeldt-Jakob disease (gCJD; one of the prion diseases) is caused by point mutations and insertions in the prion protein gene (PRNP). Previously we have reported a Chinese gCJD case with a substitution of valine (V) for glycine (G) at codon 114. To investigate the detailed pathogenic and pathologic characteristics of G114V gCJD, 10 different brain regions were thoroughly analyzed. PrP-specific...

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Source

Identifiers

PMID: 21732990
DOI: 10.1111/j.1440-1789.2011.01237.x

Genes

GFAP
PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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