Article
A genetic locus of enteropathogenic Escherichia coli necessary for the production of attaching and effacing lesions on tissue culture cells.
Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 1990
Jerse A E, Yu J, Tall B D, Kaper J B
Abstract excerpt
The ability of enteropathogenic Escherichia coli (EPEC) to form attaching and effacing intestinal lesions is a major characteristic of EPEC pathogenesis. Using TnphoA mutagenesis we have identified a chromosomal gene (eae, for E. coli attaching and effacing) that is necessary for this activity. A DNA probe derived from this gene hybridizes to 100% of E. coli of EPEC serogroups that demonstrate attaching and...
Topics
- Animals
- Bacterial Adhesion
- Cell Line
- Chromosomes, Bacterial
- Cosmids
- DNA Transposable Elements
- Escherichia coli
- Genetic Techniques
- Humans
- Molecular Sequence Data
- Mutation