Article
Evaluation of 10 genes encoding cardiac proteins in Doberman Pinschers with dilated cardiomyopathy.
American journal of veterinary research - 1 Jul 2011
O'Sullivan M Lynne, O'Grady Michael R, Pyle W Glen, Dawson John F
Abstract excerpt
OBJECTIVE: To identify a causative mutation for dilated cardiomyopathy (DCM) in Doberman Pinschers by sequencing the coding regions of 10 cardiac genes known to be associated with familial DCM in humans. ANIMALS: 5 Doberman Pinschers with DCM and congestive heart failure and 5 control mixed-breed dogs that were euthanized or died. PROCEDURES: RNA was extracted from frozen ventricular myocardial samples from each...
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