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Article

A Large-Scale Cross-Population Evaluation of Genetic Risk Variants for Dilated Cardiomyopathy in Dobermanns.

Animal genetics - 1 Oct 2026

Hulsman Alma H, Flokstra Gwen, Kijan Christina, van Rumpt Marilijn, Vernooij Johannes C M, Nelson Thomas C, Liu Sophie, Vree Lieke, Harakalova Magdalena, Ljungvall Ingrid, Haggstrom Jens, Wess Gerhard, Fieten Hille, Hytönen Marjo K, Lohi Hannes, van Steenbeek Frank G

Abstract excerpt

Previous studies suggest that genetic risk factors for dilated cardiomyopathy (DCM) in Dobermann dogs may differ between populations, complicating the use of genetic tests across subpopulations. Variants in pyruvate dehydrogenase kinase 4 (PDK4) and titin (TTN) have been associated with DCM in North American Dobermanns, whereas two loci on chromosome 5 involving Protein Kinase AMP-Activated Catalytic Subunit...

Read the complete abstract on PubMed

Topics

Animals
Cardiomyopathy, Dilated
Dogs
Polymorphism, Single Nucleotide
Dog Diseases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Europe

North America

Genetic Predisposition to Disease

Genetics, Population

Genotype

Connectin

Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 42717174
DOI: 10.1002/age.70206
PMCID: PMC13558464

Genes

RNF207
PDK4
TTN
PRKAA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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