Article
A locus on chromosome 5 is associated with dilated cardiomyopathy in Doberman Pinschers.
PloS one - 1 Jan 2011
Mausberg Theresa-Bernadette, Wess Gerhard, Simak Julia, Keller Lisa, Drögemüller Michaela, Drögemüller Cord, Webster Matthew T, Stephenson Hannah, Dukes-McEwan Joanna, Leeb Tosso
Abstract excerpt
Dilated cardiomyopathy (DCM) is a heterogeneous group of heart diseases with a strong genetic background. Currently, many human DCM cases exist where no causative mutation can be identified. DCM also occurs with high prevalence in several large dog breeds. In the Doberman Pinscher a specific DCM form characterized by arrhythmias and/or echocardiographic changes has been intensively studied by veterinary...
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