Article
Comparison of a molecular dynamics model with the X-ray structure of the N370S acid-beta-glucosidase mutant that causes Gaucher disease.
Protein engineering, design & selection : PEDS - 1 Oct 2011
Offman Marc N, Krol Marcin, Rost Burkhard, Silman Israel, Sussman Joel L, Futerman Anthony H
Abstract excerpt
Recently, two studies were published that examined the structure of the acid-β-glucosidase N370S mutant, the most common mutant that causes Gaucher disease. One study used the experimental tool of X-ray crystallography, and the other utilized molecular dynamics (MD). The two studies reinforced each other through the similarities in their findings, but each approach also added some unique information. Both studies...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.