Article
Support for down-tuning of the calreticulin gene in the process of human evolution.
Progress in neuro-psychopharmacology & biological psychiatry - 15 Aug 2011
Esmaeilzadeh-Gharehdaghi E, Banan M, Farashi S, Mirabzadeh A, Farokhashtiani T, Hosseinkhani S, Heidari A, Najmabadi H, Ohadi M
Abstract excerpt
Tissue-specific expression of the CALR gene in the brain gray matter in late-adolescence and early adulthood coincides with the expression of the psychoses phenotypes. Indeed, increased expression of the chaperone genes in the prefrontal cortex has been reported in patients affected by schizophrenia. We have previously reported cases of psychosis-associated mutations in the CALR gene promoter. One of those...
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