Article
Reversion of the human calreticulin gene promoter to the ancestral type as a result of a novel psychosis-associated mutation.
Progress in neuro-psychopharmacology & biological psychiatry - 30 Mar 2011
Farokhashtiani T, Mirabzadeh A, Olad Nabi M, Magham Z Ghaem, Khorshid H R Khorram, Najmabadi H, Ohadi M
Abstract excerpt
Development-dependent, tissue-specific expression of the calreticulin (CALR) gene in the gray matter coincides with the expression of psychoses phenotypes. We have recently reported instances of mutations within the core promoter sequence of the gene in schizoaffective disorder. In view of the mounting evidence on the genetic overlap in the psychiatric spectrum, we investigated this gene in a spectrum of patients...
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