Article
Structural analysis of histo-blood group antigen binding specificity in a norovirus GII.4 epidemic variant: implications for epochal evolution.
Journal of virology - 1 Sept 2011
Shanker Sreejesh, Choi Jae-Mun, Sankaran Banumathi, Atmar Robert L, Estes Mary K, Prasad B V Venkataram
Abstract excerpt
Susceptibility to norovirus (NoV), a major pathogen of epidemic gastroenteritis, is associated with histo-blood group antigens (HBGAs), which are also cell attachment factors for this virus. GII.4 NoV strains are predominantly associated with worldwide NoV epidemics with a periodic emergence of new variants. The sequence variations in the surface-exposed P domain of the capsid protein resulting in differential...
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