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Article

Retinoic Acid Availability Drives the Asynchronous Initiation of Spermatogonial Differentiation in the Mouse1

22 Jul 2010

Abstract excerpt

Throughout the reproductive lifespan of most male mammals, sperm production is constant because of the regulated differentiation of spermatogonia. Retinoic acid (RA) and a downstream target, Stra8, are required for complete spermatogenesis. To examine the role of RA in initiating spermatogonial differentiation, a transgenic mouse model expressing beta-galactosidase under the control of an RA response element was...

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PMID: 20650878
DOI: 10.1095/biolreprod.110.085811

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