Phosphorylation of the carbocyclic analog of 2'-deoxyguanosine in cells infected with herpes viruses.

doi:10.1016/0006-2952(90)90448-t

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Article

Phosphorylation of the carbocyclic analog of 2'-deoxyguanosine in cells infected with herpes viruses.

Biochemical pharmacology - 1 Oct 1990

Bennett L L, Shealy Y F, Allan P W, Rose L M, Shannon W M, Arnett G

Abstract excerpt

The carbocyclic analog of 2'-deoxyguanosine [(+-)-2-amino-1,9-dihydro-9-[(1 alpha,3 beta,4 alpha)-3-hydroxy-4-(hydroxymethyl)cyclopentyl]-6H-purine-6-one] (2'-CDG) is highly active in cell culture against strains S148 and E377 of herpes simplex virus type 1 (HSV-1), both of which code for thymidi...

Topics

Animals
Antiviral Agents
Cell Line
Chromatography, High Pressure Liquid
Deoxyguanosine
Herpes Simplex
Mutation
Nucleotides
Phosphorylation
Simplexvirus
Thymidine Kinase

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