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Article

Oxidative stress-induced apoptosis in two patients with Alagille syndrome.

Journal of the neurological sciences - 15 Sept 2011

Radi Elena, Formichi Patrizia, Di Maio Giuseppe, Battisti Carla, Federico Antonio

Abstract excerpt

Alagille syndrome (AGS) is an autosomal dominant disorder characterized by cholestasis, cardiac, skeletal and ocular abnormalities. Increasing importance is being given to vascular and central nervous system impairment. AGS is in most cases caused by heterozygous mutations in the Jagged-1 (JAG1) gene encoding a cell-surface ligand of the Notch receptors. The interaction between Notch1 and JAG1 induces...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21714972
DOI: 10.1016/j.jns.2011.06.025

Genes

JAG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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