Article
Controlled clinical trial with pirfenidone in the treatment of breast capsular contracture: association of TGF-β polymorphisms.
Annals of plastic surgery - 1 Jan 2013
Veras-Castillo Evelin Rosaira, Cardenas-Camarena Lazaro, Lyra-Gonzalez Ivan, Muñoz-Valle Jose Francisco, Lucano-Landeros Silvia, Guerrerosantos Jose, Gonzalez-Ulloa Beatriz, Mercado-Barajas Jose Luis, Sanchez-Parada Maria Guadalupe, Azabache-Wennceslao Ronney, Armendariz-Borunda Juan
Abstract excerpt
BACKGROUND: Breast capsular contracture (BCC) is a commonly adverse event postmammoplastly characterized by an immune response mediated by cytokines and transforming growth factor (TGF)-β1 resulting in excessive synthesis and deposit of extracellular matrix around the breast implant. Presence of TGF-β1 polymorphisms has been associated as a risk factor to develop fibroproliferative diseases. METHODS: This open,...
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