Article
Melanization of a meristematic mutant of Fonsecaea monophora increases tolerance to stress factors while no effects on antifungal susceptibility.
Mycopathologia - 1 Nov 2011
Sun Jiufeng, Zhang Junmin, Najafzadeh M J, Badali Hamid, Li Xiqing, Xi Liyan, de Hoog G S
Abstract excerpt
Melanin is a complex polymer, which is widely distributed in nature, and is known as an important virulence factor in opportunistic and pathogenic fungi. In this study, three melanin mutants of Fonsecaea monophora from a case of chromoblastomycosis were generated from a parent strain that lacked hyphal morphology but was meristematic instead. Two albino mutants, one of which (CBS 125187) produced secreted melanin...
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