Article
TIRAP Ser180Leu polymorphism is associated with Behcet's disease.
Rheumatology (Oxford, England) - 1 Oct 2011
Durrani Omar, Banahan Katherine, Sheedy Frederick J, McBride Laura, Ben-Chetrit Eldad, Greiner Kathryn, Vaughan Robert W, Kondeatis Elli, Hamburger John, Fortune Farida, Stanford Miles R, Murray Philip I, O'Neill Luke A, Wallace Graham R
Abstract excerpt
OBJECTIVES: The initiating cause of Behçet's disease (BD) is unknown, but an aberrant response to infection has been suggested. In this study, single nucleotide polymorphisms in Toll-like receptors (TLRs) and associated molecules that have a sentinel function at mucosal surfaces were analysed in patients with BD. METHODS: TLR expression was determined by immunohistochemistry in buccal mucosal tissue from patients...
Topics
- Behcet Syndrome
- DNA
- Granuloma, Pyogenic
- Humans
- Leucine
- Lichen Planus
- Lipopolysaccharide Receptors
- Membrane Glycoproteins
- Mouth Mucosa
- Polymorphism, Single Nucleotide
- Receptors, Interleukin-1
- Serine
- Toll-Like Receptor 2