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Article

DRC2/CCDC65 is a central hub for assembly of the nexin-dynein regulatory complex and other regulators of ciliary and flagellar motility.

Molecular biology of the cell - 15 Jan 2018

Bower Raqual, Tritschler Douglas, Mills Kristyn VanderWaal, Heuser Thomas, Nicastro Daniela, Porter Mary E

Abstract excerpt

The nexin-dynein regulatory complex (N-DRC) plays a central role in the regulation of ciliary and flagellar motility. In most species, the N-DRC contains at least 11 subunits, but the specific function of each subunit is unknown. Mutations in three subunits (DRC1, DRC2/CCDC65, DRC4/GAS8) have been linked to defects in ciliary motility in humans and lead to a ciliopathy known as primary ciliary dyskinesia (PCD)....

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Identifiers

PMID: 29167384
DOI: 10.1091/mbc.E17-08-0510
PMCID: PMC5909927

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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DRC2/CCDC65 is a central hub for assembly of the nexin-dynein regulatory complex and other regulators of ciliary and flagellar motility.PMID 29167384Read ↗

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