Article
Functional analysis of the internal translation initiation site of foot-and-mouth disease virus.
Journal of virology - 1 Oct 1990
Kühn R, Luz N, Beck E
Abstract excerpt
Mutagenesis of the large untranslated sequence at the 5' end of the genome of foot-and-mouth disease virus revealed that a region of approximately 450 nucleotides preceding the open reading frame of the viral polyprotein is involved in the regulation of translation initiation at two internal start sites. Variations in two domains of this region reduced the translation efficiency up to 10-fold, whereas an...
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