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Article

Polymorphism C1420T of Serine hydroxymethyltransferase gene on maternal risk for Down syndrome.

Molecular biology reports - 1 Mar 2012

Marucci Gustavo Henrique, Zampieri Bruna Lancia, Biselli Joice Matos, Valentin Sendi, Bertollo Eny Maria Goloni, Eberlin Marcos Nogueira, Haddad Renato, Riccio Maria Francesca, Vannucchi Hélio, Carvalho Valdemir Melechco, Pavarino Erika Cristina

Abstract excerpt

Recent researches have investigated the factors that determine the maternal risk for Down syndrome (DS) in young woman. In this context, some studies have demonstrated the association between polymorphisms in genes involved on folate metabolism and the maternal risk for DS. These polymorphisms may result in abnormal folate metabolism and methyl deficiency, which is associated with aberrant chromosome segregation...

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PMID: 21687976
DOI: 10.1007/s11033-011-1008-7

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