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Essential role of maternal UCHL1 and UCHL3 in fertilization and preimplantation embryo development

15 Jun 2011

Abstract excerpt

Post-translational protein modification by ubiquitination, a signal for lysosomal or proteasomal proteolysis, can be regulated and reversed by deubiquitinating enzymes (DUBs). This study examined the roles of UCHL1 and UCHL3, two members of ubiquitin C-terminal hydrolase (UCH) family of DUBs, in murine fertilization and preimplantation development. Before fertilization, these proteins were associated with the...

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PMID: 21678411
DOI: 10.1002/jcp.22876

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