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In Vivo Fluorescence Spectra Unmixing and Autofluorescence Removal by Sparse Nonnegative Matrix Factorization

20 Jun 2011

Abstract excerpt

Fluorescence imaging locates fluorescent markers that specifically bind to targets; like tumors, markers are injected to a patient, optimally excited with near-infrared light, and located thanks to backward-emitted fluorescence analysis. To investigate thick and diffusive media, as the fluorescence signal decreases exponentially with the light travel distance, the autofluorescence of biological tissues comes to...

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PMID: 21672672
DOI: 10.1109/tbme.2011.2159382

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