Article
A cascade of coregulating enhancer binding proteins initiates and propagates a multicellular developmental program.
Proceedings of the National Academy of Sciences of the United States of America - 9 Aug 2011
Giglio Krista M, Caberoy Nora, Suen Garret, Kaiser Dale, Garza Anthony G
Abstract excerpt
The signal transduction networks that initiate multicellular development in bacteria remain largely undefined. Here, we report that Myxococcus xanthus regulates entry into its multicellular developmental program using a novel strategy: a cascade of transcriptional activators known as enhancer binding proteins (EBPs). The EBPs in the cascade function in sequential stages of early development, and several lines of...
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