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Article

Adaptive evolution of an sRNA that controls Myxococcus development.

Science (New York, N.Y.) - 21 May 2010

Yu Yuen-Tsu N, Yuan Xi, Velicer Gregory J

Abstract excerpt

Small RNA (sRNA) molecules regulate a vast array of processes in biology, but evidence for adaptive evolution of sRNA sequences has been indirect. Here, we identify an sRNA, Pxr, that negatively regulates fruiting body development in Myxococcus xanthus. We further show that a spontaneous evolutionary mutation in Pxr abolished its regulatory function and thereby adaptively restored developmental proficiency to a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20489016
DOI: 10.1126/science.1187200
PMCID: PMC3027070

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