Article
A targeted CRISPR-Cas9 mediated F0 screen identifies genes involved in establishment of the enteric nervous system
2023-12-29
Abstract excerpt
The vertebrate enteric nervous system (ENS) is a crucial network of enteric neurons and glia resident within the entire gastrointestinal tract (GI). Overseeing essential GI functions such as gut motility and water balance, the ENS serves as a pivotal bidirectional link in the gut-brain axis. During early development, the ENS is primarily derived from enteric neural crest cells (ENCCs). Disruptions to ENCC developm...
Topics
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- Congenital Anomalies and Fetal Surgery
- Congenital gastrointestinal and neural anomalies
- Congenital heart defects research
- Digestive system and related health
- Gastrointestinal motility and disorders
- Intestinal Malrotation and Obstruction Disorders
- RNA regulation and disease
- Single-cell and spatial transcriptomics
Identifiers and source
- Literature Corpus work
- ebf22a7b-388d-5240-956a-ba5d5db57d12
- DOI
- 10.1101/2023.12.28.573581