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Article

Hypoxia-Driven Gene Expression Is an Independent Prognostic Factor in Stage II and III Colon Cancer Patients

31 Jan 2014

Abstract excerpt

PURPOSE: Hypoxia is considered a major microenvironmental factor influencing cancer behavior. Our aim was to develop a hypoxia-based gene score that could identify high and low risk within stage II and III colon cancer patients. EXPERIMENTAL DESIGN: Differential gene expression of CaCo-2 colon cancer cells cultured in chronic hypoxia versus normoxia was tested for correlation with prognostic variables in...

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PMID: 24486594
DOI: 10.1158/1078-0432.ccr-13-2958

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