Article
Conserved arginine residue in the membrane-spanning domain of HIV-1 gp41 is required for efficient membrane fusion.
Protein & cell - 1 May 2011
Long Yufei, Meng Fanxia, Kondo Naoyuki, Iwamoto Aikichi, Matsuda Zene
Abstract excerpt
Despite the high mutation rate of HIV-1, the amino acid sequences of the membrane-spanning domain (MSD) of HIV-1 gp41 are well conserved. Arginine residues are rarely found in single membrane-spanning domains, yet an arginine residue, R(696) (the numbering is based on that of HXB2), is highly conserved in HIV-1 gp41. To examine the role of R(696), it was mutated to K, A, I, L, D, E, N, and Q. Most of these...
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