Article
Mutations of conserved glycine residues within the membrane-spanning domain of human immunodeficiency virus type 1 gp41 can inhibit membrane fusion and incorporation of Env onto virions.
Japanese journal of infectious diseases - 1 Apr 2006
Miyauchi Kosuke, Curran Rachael, Matthews Erin, Komano Jun, Hoshino Tyuji, Engelman Don M, Matsuda Zene
Abstract excerpt
The membrane-spanning domain (MSD) of HIV-1 envelope protein (Env) has an additional glycine residue within a well-conserved putative transmembrane helix-helix interaction motif, GXXXG, and forms a G(690)G(691)XXG(694) sequence (G, glycine; X, any residues; the numbering indicates the position wi...
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