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Effect of different UCOE-promoter combinations in creation of engineered cell lines for the production of Factor VIII

10 Jun 2011

Abstract excerpt

BACKGROUND: The most common approach used in generating cell lines for the production of therapetic proteins relies on gene amplification induced by a drug resistance gene e. g., DHFR and glutamine synthetase. Practically, this results in screening large number of clones for the one that expresses high levels of the biologic in a stable manner. The inefficiency of mammalian vector systems to express proteins in a...

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PMID: 21663669
DOI: 10.1186/1756-0500-4-178

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