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Pathway-driven gene stability selection of two rheumatoid arthritis GWAS identifies and validates new susceptibility genes in receptor mediated signalling pathways.

Human molecular genetics - 1 Sept 2011

Eleftherohorinou Hariklia, Hoggart Clive J, Wright Victoria J, Levin Michael, Coin Lachlan J M

Abstract excerpt

Rheumatoid arthritis (RA) is the commonest chronic, systemic, inflammatory disorder affecting ∼1% of the world population. It has a strong genetic component and a growing number of associated genes have been discovered in genome-wide association studies (GWAS), which nevertheless only account for 23% of the total genetic risk. We aimed to identify additional susceptibility loci through the analysis of GWAS in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21653640
DOI: 10.1093/hmg/ddr248

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