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PCR Master Mixes Harbour Murine DNA Sequences. Caveat Emptor!

25 May 2011

Abstract excerpt

BACKGROUND: XMRV is the most recently described retrovirus to be found in Man, firstly in patients with prostate cancer (PC) and secondly in 67% of patients with chronic fatigue syndrome (CFS) and 3.7% of controls. Both disease associations remain contentious. Indeed, a recent publication has concluded that "XMRV is unlikely to be a human pathogen". Subsequently related but different polytropic MLV (pMLV)...

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PMID: 21647447
DOI: 10.1371/journal.pone.0019953

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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PCR Master Mixes Harbour Murine DNA Sequences. Caveat Emptor!PMID 21647447Read ↗

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Disease-associated XMRV sequences are consistent with laboratory contaminationSemantic proximity Read ↗

Failure to Detect the Novel Retrovirus XMRV in Chronic Fatigue SyndromeSemantic proximity Read ↗

DNA Extraction Columns Contaminated with Murine SequencesSemantic proximity Read ↗

Multiple sources of contamination in samples from patients reported to have XMRV infection.Semantic proximity Read ↗

No Evidence for XMRV Nucleic Acids, Infectious Virus or Anti-XMRV Antibodies in Canadian Patients with Chronic Fatigue SyndromeSemantic proximity Read ↗

No Evidence of Murine-Like Gammaretroviruses in CFS Patients Previously Identified as XMRV-InfectedSemantic proximity Read ↗

Biology and pathophysiology of the new human retrovirus XMRV and its association with human disease.Semantic proximity Read ↗

Contamination of clinical specimens with MLV-encoding nucleic acids: implications for XMRV and other candidate human retrovirusesSemantic proximity Read ↗

Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndromeSemantic proximity Read ↗

No Evidence of XMRV or Related Retroviruses in a London HIV-1-Positive Patient CohortSemantic proximity Read ↗

An Endogenous Murine Leukemia Viral Genome Contaminant in a Commercial RT-PCR Kit is Amplified Using Standard Primers for XMRVSemantic proximity Read ↗

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