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Article

Molecular genetic and functional characterization implicate muscle-restricted coiled-coil gene (MURC) as a causal gene for familial dilated cardiomyopathy.

Circulation. Cardiovascular genetics - 1 Aug 2011

Rodriguez Gabriela, Ueyama Tomomi, Ogata Takehiro, Czernuszewicz Grazyna, Tan Yanli, Dorn Gerald W, Bogaev Roberta, Amano Katsuya, Oh Hidemasa, Matsubara Hiroaki, Willerson James T, Marian Ali J

Abstract excerpt

BACKGROUND: Dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM) are classic forms of systolic and diastolic heart failure, respectively. Mutations in genes encoding sarcomere and cytoskeletal proteins are major causes of HCM and DCM. MURC, encoding muscle-restricted coiled-coil, a Z-line protein, regulates cardiac function in mice. We investigated potential causal role of MURC in human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21642240
DOI: 10.1161/CIRCGENETICS.111.959866
PMCID: PMC3157556

Genes

MYH7
TPM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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