Article
Polymorphisms in stromal genes and susceptibility to serous epithelial ovarian cancer: a report from the Ovarian Cancer Association Consortium.
PloS one - 1 Jan 2011
Amankwah Ernest K, Wang Qinggang, Schildkraut Joellen M, Tsai Ya-Yu, Ramus Susan J, Fridley Brooke L, Beesley Jonathan, Johnatty Sharon E, Webb Penelope M, Chenevix-Trench Georgia, Dale Laura C, Lambrechts Diether, Amant Frederic, Despierre Evelyn, Vergote Ignace, Gayther Simon A, Gentry-Maharaj Aleksandra, Menon Usha, Chang-Claude Jenny, Wang-Gohrke Shan, Anton-Culver Hoda, Ziogas Argyrios, Dörk Thilo, Dürst Matthias, Antonenkova Natalia, Bogdanova Natalia, Brown Robert, Flanagan James M, Kaye Stanley B, Paul James, Bützow Ralf, Nevanlinna Heli, Campbell Ian, Eccles Diana M, Karlan Beth Y, Gross Jenny, Walsh Christine, Pharoah Paul D P, Song Honglin, Krüger Kjær Susanne, Høgdall Estrid, Høgdall Claus, Lundvall Lene, Nedergaard Lotte, Kiemeney Lambertus A L M, Massuger Leon F A G, van Altena Anne M, Vermeulen Sita H H M, Le Nhu D, Brooks-Wilson Angela, Cook Linda S, Phelan Catherine M, Cunningham Julie M, Vachon Celine M, Vierkant Robert A, Iversen Edwin S, Berchuck Andrew, Goode Ellen L, Sellers Thomas A, Kelemen Linda E
Abstract excerpt
Alterations in stromal tissue components can inhibit or promote epithelial tumorigenesis. Decorin (DCN) and lumican (LUM) show reduced stromal expression in serous epithelial ovarian cancer (sEOC). We hypothesized that common variants in these genes associate with risk. Associations with sEOC among Caucasians were estimated with odds ratios (OR) among 397 cases and 920 controls in two U.S.-based studies...
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