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Article

A reduced representation approach to population genetic analyses and applications to human evolution.

Genome research - 1 Jul 2011

Luca Francesca, Hudson Richard R, Witonsky David B, Di Rienzo Anna

Abstract excerpt

Second-generation sequencing technologies allow surveys of sequence variation on an unprecedented scale. However, despite the rapid decrease in sequencing costs, collecting whole-genome sequence data on a population scale is still prohibitive for many laboratories. We have implemented an inexpensive, reduced representation protocol for preparing resequencing targets, and we have developed the analytical tools...

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Identifiers

PMID: 21628451
DOI: 10.1101/gr.119792.110
PMCID: PMC3129251

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