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Article

Quantifying differential gene connectivity between disease states for objective identification of disease-relevant genes.

BMC systems biology - 31 May 2011

Chu Jen-hwa, Lazarus Ross, Carey Vincent J, Raby Benjamin A

Abstract excerpt

BACKGROUND: Network modeling of whole transcriptome expression data enables characterization of complex epistatic (gene-gene) interactions that underlie cellular functions. Though numerous methods have been proposed and successfully implemented to develop these networks, there are no formal methods for comparing differences in network connectivity patterns as a function of phenotypic trait. RESULTS: Here we...

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Identifiers

PMID: 21627793
DOI: 10.1186/1752-0509-5-89
PMCID: PMC3128864

Genes

CXCL13
MMP12

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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