Article
On the role of flexibility in protein-ligand interactions: the example of p53 tetramerization domain.
Chemistry, an Asian journal - 6 Jun 2011
Gordo Susana, Martos Vera, Vilaseca Marta, Menéndez Margarita, de Mendoza Javier, Giralt Ernest
Abstract excerpt
The recognition of protein surfaces by designed ligands has become an attractive approach in drug discovery. However, the variable nature and irregular behavior of protein surfaces defy this new area of research. The easy to understand "lock-and-key" model is far from being the ideal paradigm in biomolecular interactions and, hence, any new finding on how proteins and ligands behave in recognition events paves a...
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