Article
Hepatitis C viral evolution in genotype 1 treatment-naïve and treatment-experienced patients receiving telaprevir-based therapy in clinical trials.
PloS one - 1 Jan 2012
Kieffer Tara L, De Meyer Sandra, Bartels Doug J, Sullivan James C, Zhang Eileen Z, Tigges Ann, Dierynck Inge, Spanks Joan, Dorrian Jennifer, Jiang Min, Adiwijaya Bambang, Ghys Anne, Beumont Maria, Kauffman Robert S, Adda Nathalie, Jacobson Ira M, Sherman Kenneth E, Zeuzem Stefan, Kwong Ann D, Picchio Gaston
Abstract excerpt
BACKGROUND: In patients with genotype 1 chronic hepatitis C infection, telaprevir (TVR) in combination with peginterferon and ribavirin (PR) significantly increased sustained virologic response (SVR) rates compared with PR alone. However, genotypic changes could be observed in TVR-treated patients who did not achieve an SVR. METHODS: Population sequence analysis of the NS3•4A region was performed in patients who...
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