Article
CTL recognition of a novel HLA-A*0201-binding peptide derived from glioblastoma multiforme tumor cells.
Cancer immunology, immunotherapy : CII - 1 Sept 2011
Myers Cheryl E, Hanavan Paul, Antwi Kwasi, Mahadevan Daruka, Nadeem A Jamal, Cooke Laurence, Scheck Adrienne C, Laughrey Zachary, Lake Douglas F
Abstract excerpt
Genetic instability of tumor cells can result in translation of proteins that are out of frame, resulting in expression of neopeptides. These neopeptides are not self-proteins and therefore should be immunogenic. By eluting peptides from human glioblastoma multiforme (GBM) tumor cell surfaces and subjecting them to tandem mass spectrometry, we identified a novel peptide (KLWGLTPKVTPS) corresponding to a...
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