Article
Expression of staphylococcal superantigens during nasal colonization is not sufficient to induce a systemic neutralizing antibody response in humans.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 1 Mar 2012
Burian M, Grumann D, Holtfreter S, Wolz C, Goerke C, Bröker B M
Abstract excerpt
Staphylococcus aureus carriers have high-titer serum antibodies against non-enterotoxin gene cluster (egc) superantigens, whereas they lack anti-egc antibodies, suggesting different superantigen expression profiles in vivo. We measured the superantigen transcripts in S. aureus directly isolated from the nose of persistent carriers and correlated them with the superantigen-neutralizing antibody response. While...
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