Improved genetic association tests for an ordinal outcome representing the disease progression process.

Abstract excerpt

We are interested in detecting genetic variants that influence transition between discrete stages of a disease progression process, such as the natural history of progression to cervical cancer with the following four stages: (1) normal-human papillomavirus (HPV) exposed, (2) persistent infection with oncogenic HPV, (3) cervical intraepithelial neoplasia grades 2 or 3 (CIN2/3), and (4) cervical cancer. Standard...

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