Article
Polyamines protect Escherichia coli cells from the toxic effect of oxygen.
Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2003
Chattopadhyay Manas K, Tabor Celia White, Tabor Herbert
Abstract excerpt
Wild-type Escherichia coli cells grow normally in 95% O(2)/5% CO(2). In contrast, cells that cannot make polyamines because of mutations in the biosynthetic pathway are rapidly killed by incubation in 95% O(2)/5% CO(2). Addition of polyamines prevents the toxic effect of oxygen, permitting cell survival and optimal growth. Oxygen toxicity can also be prevented if the growth medium contains an amino acid mixture...
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