Article
The oxygen effect: variation of the K-value and lifetimes of O2-dependent damage in some glutathione-deficient mutants of Escherichia coli.
International journal of radiation biology - 1 May 1991
Harrop H A, Held K D, Michael B D
Abstract excerpt
Radiosensitization by various concentrations of O2 has been studied in an Escherichia coli K-12 wild-type strain and some derived glutathione (GSH)-deficient mutants using 60Co gamma-irradiation. The maximum oxygen enhancement ratio (OER) and the K-value, the O2 concentration that produced half the maximum O2 effect, were found to depend on the GSH biosynthetic capacity of the strains. For the GSH+ wild-type...
Topics
- Cobalt Radioisotopes
- DNA Damage
- Escherichia coli
- Gamma Rays
- Glutathione
- Mutation
- Oxygen
- Radiation-Sensitizing Agents