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Article

Genetic analysis of hyperpolarization-activated cyclic nucleotide-gated cation channels in sudden unexpected death in epilepsy cases.

Brain pathology (Zurich, Switzerland) - 1 Nov 2011

Tu Emily, Waterhouse Louise, Duflou Johan, Bagnall Richard D, Semsarian Christopher

Abstract excerpt

Sudden unexpected death in epilepsy (SUDEP) is the most common epilepsy-related cause of death, yet the cause is unknown. Our previous studies suggest a role for arrhythmia-related ion channel genes in the pathogenesis of SUDEP. Hyperpolarization-activated cyclic nucleotide-gated cation (HCN1-4) channels are ion channels involved in generating spontaneous rhythmic activity in cardiac pacemaker and neuronal cells....

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Source

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Identifiers

PMID: 21615589
DOI: 10.1111/j.1750-3639.2011.00500.x
PMCID: PMC8094053

Genes

HCN1
HCN2
HCN4
HCN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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