Genes transferred by retroviral vectors into normal and mutant myoblasts in primary cultures are expressed in myotubes.

doi:10.1128/mcb.10.6.3268-3271.1990

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Article

Genes transferred by retroviral vectors into normal and mutant myoblasts in primary cultures are expressed in myotubes.

Molecular and cellular biology - 1 Jun 1990

Smith B F, Hoffman R K, Giger U, Wolfe J H

Abstract excerpt

Retroviral vectors were used to transfer genes efficiently into rat and dog myoblasts in primary cultures under conditions which permitted the transduced myoblasts to differentiate into myotubes expressing the transferred genes. The transduced myotubes expressed normal markers of differentiation...

Topics

Animals
Cell Differentiation
Cells, Cultured
Dogs
Fetus
Genes, Bacterial
Glucuronidase
Kanamycin Kinase
Muscles
Mutation
Phosphotransferases
Rats
Rats, Inbred Strains
Retroviridae
Transfection

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