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Article

Genes in the terminal regions of orthopoxvirus genomes experience adaptive molecular evolution.

BMC genomics - 23 May 2011

Esteban David J, Hutchinson Anne P

Abstract excerpt

BACKGROUND: Orthopoxviruses are dsDNA viruses with large genomes, some encoding over 200 genes. Genes essential for viral replication are located in the center of the linear genome and genes encoding host response modifiers and other host interacting proteins are located in the terminal regions. The central portion of the genome is highly conserved, both in gene content and sequence, while the terminal regions...

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Identifiers

PMID: 21605412
DOI: 10.1186/1471-2164-12-261
PMCID: PMC3123329

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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