Article
Studies on galactofuranose-containing glycostructures of the pathogenic mold Aspergillus fumigatus.
International journal of medical microbiology : IJMM - 1 Aug 2011
Heesemann Leonie, Kotz Andrea, Echtenacher Bernd, Broniszewska Marzena, Routier Françoise, Hoffmann Petra, Ebel Frank
Abstract excerpt
Galactofuranose is a hexose that is exclusively found in microbes and in particular in certain pathogenic species. In the mold Aspergillus fumigatus, it is the characteristic constituent of the cell wall component galactomannan. Detection of this carbohydrate is currently a widespread method used for diagnosis of systemic A. fumigatus infections. In this study, we raised and characterized 2 monoclonal antibodies...
Topics
- Animals
- Antibodies, Monoclonal
- Antigens, Fungal
- Aspergillosis
- Aspergillus fumigatus
- Cell Wall
- Complement C1q
- Electrophoresis, Polyacrylamide Gel
- Galactose
- Humans
- Hybridomas
- Hyphae
- Immunoglobulin M
- Interleukin-10