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Article

Widespread RNA and DNA sequence differences in the human transcriptome.

Science (New York, N.Y.) - 1 Jul 2011

Li Mingyao, Wang Isabel X, Li Yun, Bruzel Alan, Richards Allison L, Toung Jonathan M, Cheung Vivian G

Abstract excerpt

The transmission of information from DNA to RNA is a critical process. We compared RNA sequences from human B cells of 27 individuals to the corresponding DNA sequences from the same individuals and uncovered more than 10,000 exonic sites where the RNA sequences do not match that of the DNA. All 12 possible categories of discordances were observed. These differences were nonrandom as many sites were found in...

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Identifiers

PMID: 21596952
DOI: 10.1126/science.1207018
PMCID: PMC3204392

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